An estimated 6 to 7 million people have been infected with T.
2021 Santos Silva et al., 2021).Ĭhagas disease in recent decades has been detected in several countries outside Latin America, including the United States of America and Canada, European countries and some African, Eastern Mediterranean and Western Pacific countries. Approximately 350 million people are at risk in 88 countries around the world (Ruiz-Postigo et al. According to the WHO it is estimated that 12 million people are affected by cutaneous or visceral leishmaniasis, and about 2 million infections occur each year. Leishmaniasis has a wide range of clinical symptoms. Epidemiological data show that cases of NTDs have become a serious public health problem. cruzi), Schistosoma mansoni, Plasmodium falciparum, among others are included. In this context, some parasitoses caused by Leishmania species, Trypanosoma cruzi ( T. According to the World Health Organization (WHO), 17 diseases are part of this group, affecting about 1 billion people in the world, with 70% of the affected territories being low- and middle-income economies (Ramsay et al., 2016 World Health Organization, 2018 Ruiz-Postigo et al. Neglected tropical diseases (NTDs) refer to a group of global health problems caused mainly by parasitic organisms affecting a population with low socioeconomic status, causing high rates of morbidity and mortality. This study shows in a preliminary way that the synthesized compounds have antiparasitic potential in vitro.
In contrast, thiazoles promoted growth inhibition. As for the in vitro antimalarial activity, thiosemicarbazones did not inhibit Plasmodium falciparum growth. Among the compounds, 1b, 1j and 2l stood out, showing inhibition potential for the amastigote forms of the two parasites. In relation to in vitro antiparasitic activity, thiosemicarbazones and thiazoles showed cytotoxic potential against the parasites Leishmania amazonensis and Trypanosoma cruzi. Screening assays to assess the toxicity of compounds to mammalian cells revealed that thiosemicarbazones were less toxic when compared to thiazoles. In addition, they were able to interact with albumin and DNA. In assays of antioxidant activity, thiosemicarbazones showed moderate to high antioxidant potential when compared to thiazoles. The pharmacokinetic properties obtained in silico revealed that the derivatives are in accordance with the parameters established by lipinski and veber, showing that such compounds have good bioavailability or permeability when administered orally. In this work, 13 thiosemicarbazones (1a – m) and 16 thiazoles (2a – p) were obtained, which were properly characterized by spectroscopic and spectrometric techniques.
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